Furthermore, we investigated the effects of a combination of sotorasib with the cytotoxic chemotherapy pemetrexed, one of the standard treatments for lung adenocarcinoma, and confirmed that pemetrexed did not enhance the efficacy of sotorasib, unlike the combination of sotorasib and WEE1 inhibitors (Figure S9A). This evidence concerns the gene WEE1 and lung adenocarcinoma.