In IHD, the top activated pathways (based on activation Z score by IPA) were sirtuin signaling pathway, protein kinase A signaling, eNOS signaling, and dilated cardiomyopathy signaling for the LAM1 population and cardiac hypertrophy (enhanced), phagosome formation, wound healing and fibrosis signaling pathways for LAM2. This evidence concerns the gene SELL and myocardial ischemia.