In IHD, the top activated pathways (based on activation Z score by IPA) were sirtuin signaling pathway, protein kinase A signaling, eNOS signaling, and dilated cardiomyopathy signaling for the LAM1 population and cardiac hypertrophy (enhanced), phagosome formation, wound healing and fibrosis signaling pathways for LAM2. The gene discussed is SELL; the disease is dilated cardiomyopathy.