RIGI and viral infectious disease: The observation that the assembly of ADAP-RIG-I complex can be induced by SeV infection (Fig 2B) indicates RIG-I stability could be more dependent on ADAP in macrophages in the context of viral infection than in resting context, contributing to explain why ADAP deficiency causes a significant decrease in RIG-I protein in SeV-infected macrophages but not in the resting macrophages.