As shown in Fig 7A and 7B, upon IAV-PR8 infection, the percentage of macrophages positively stained for both F4/80 and NP protein were robustly higher (approximately 2-fold) in both lung and spleen from Adap-/- mice compared to that from WT mice, confirming that macrophages from both lung and spleen of Adap-/- mice are more susceptible to IAV infection. Here, FYB1 is linked to infection.