CALB1 and schizophrenia: As both loss of neuronal firing and/or sustained increases in calcium signaling can induce dendritic atrophy,25 this mechanism could also contribute to the selective changes in spines and dendrites in layer III of the dlPFC in schizophrenia.11 It is not known if the layer III dlPFC pyramidal cells with altered dendrites in schizophrenia express calbindin, prior to descent into illness for instance, an important area for future research.