Risk of schizophrenia has also been associated with variants in GRIN2B,56 although alterations in this receptor are more often associated with more general neurodevelopmental intellectual impairment, consistent with the key roles of this receptor in neuronal and circuit development.57 It is likely that alterations in CACNA1C also contribute to neurodevelopmental insults,58 including possible alterations in dendritic morphology59 and/or interneuron migration.60 However, the current data emphasize that altered CACNA1C LTCC function can also impact higher cognitive abilities in the adult dlPFC. This evidence concerns the gene GRIN2B and Cognitive impairment.