In this study, the dorsolateral prefrontal cortical pyramidal cells most affected in cognitive disorders express elevated calcium-related signaling, delineated by CALB1 (calcium-buffering protein calbindin), and high CACNA1C (L-type calcium channel [LTCC] Cav1.2), GRIN2B (NMDA receptor GluN2B), and KCNN3 (SK3 channel) expression. Here, CALB1 is linked to Cognitive impairment.