Gabapentin dose-dependently reduced neuronal injury induced by cerebral ischemia-reperfusion preventing the oxidative stress-related autophagy via the activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin (mTOR) (PI3K/Akt/mTOR) pathway [123]. This evidence concerns the gene MTOR and brain ischemia.