However, DHCR24 is lower expressed in advanced tumors than in early tumors and normal tissues, and force expressed DHCR24 inhibits cell growth in prostate cancer [22, 23], suggesting that that cholesterol or its metabolites play a promoting or inhibitory role in tumorigenesis, depending on the type and stage of cancer [24, 25]. This evidence concerns the gene DHCR24 and Familial prostate cancer.