In agreement with our immunoblot data, among the significantly more abundant proteins in the multiple CTS-depleted cells were lysosomal membrane proteins like LAMP1, LAMP2, but also LIMP2 (Lysosomal integral membrane protein 2), and PLD3 (Phospholipase D3), the autophagy marker p62 (Sequestosome-1, SQSTM1), proteins involved in cell adhesion like ITGA1 (Integrin alpha-1) and ITGA2 (Integrin alpha-2) and proteins involved in neurodegenerative diseases like APP (Amyloid Precursor Protein), and LRP1 (Low density lipoprotein receptor-related protein 1). This evidence concerns the gene PLD3 and neurodegenerative disease.