Additionally, ROCK2 was identified as the direct target of miR-101a-3p.<h4>Conclusion</h4>MiR-101a-3p can reduce neuronal apoptosis and neurological deficit in PD mice by inhibiting ROCK2 expression, suggesting that miR-101a-3p is a promising therapeutic target for PD. The gene discussed is ROCK2; the disease is Parkinson disease.