Theresults revealed that FRZB was an important protection factor of patients withadvanced HNSCC (Figure 3B and C).Univariate Cox regression analysis showed that FRZB was closely related tooverall survival, and multivariate regression analysis further indicated thatFRZB may be an independent prognostic factor for HNSCC patients (Figure 3D and E). Here, FRZB is linked to head and neck squamous cell carcinoma.