In an animal experiment conducted by Yamada et al.33, to determine the effect of inhibiting cathepsin-L on T cell-mediated autoimmunity, they found that inhibition of cathepsin-L prevented the cytotoxic activity of CD8+ T cells in pancreatic islets in mice with autoimmune type 1 diabetes. The gene discussed is CTSL; the disease is autoimmune type 1 diabetes.