IFNG and Splenomegaly: Interestingly, inhibition of IFNγ has been shown to be effective in reducing several of the pathologies associated with hyperinflammation in CpG-induced MAS, including splenomegaly, anaemia, thrombocytopenia and hypercytokinaemia (Behrens et al., 2011; Gao et al., 2021).