Here, we show that components of the NLRP3 inflammasome were upregulated following induction of CpG-induced hyperinflammation, and that inflammasomes were critical for the induction of IL-18, a key cytokine involved in the clinical manifestations of MAS (Shiga et al., 2021; Krei et al., 2021; Weiss et al., 2018). Here, IL18 is linked to macrophage activation syndrome.