Our data demonstrated that IL-18 is not essential for the development of characteristics associated with hyperinflammatory disease, including hyperferritinaemia, splenomegaly and cytokine storm, mirroring the results observed in response to direct inhibition of IL-18 signalling (Girard-Guyonvarc'h et al., 2018). This evidence concerns the gene IL18 and Splenomegaly.