It has been reported that Crocin can inhibit the progression of neurological diseases (such as AD, retinal ischemia/reperfusion (IR) injury, and cerebral infarction) by regulating the PI3K/AKT pathway (Qi et al., 2013; Taheri et al., 2021; Zhao et al., 2022). The gene discussed is AKT1; the disease is Alzheimer disease.