The dual and contradictory role of HSP90 is also demonstrated by the protective action of Hsp90/Cdc37 complex toward ubiquitination and proteasomal degradation of mixed lineage kinase 3, the loss of which promotes melanoma cell invasion via interaction between Hsp90/Cdc37 and BRAF and extracellular signal‐regulated kinases (ERK) hyperactivation.31 Here, BRAF is linked to melanoma.