In melanoma, circulating heat shock protein 70 (HSP70) as the primary effector of NLRP3 triggering a distant TLR4‐dependent signaling cascade (NLRP3‐HSP70‐TLR4 axis), regulates granulopoiesis and recruitment and the accumulation of PMN‐MDSCs in distant organs, thus supporting the creation of a premetastatic niche.23 This evidence concerns the gene TLR4 and melanoma.