Autocrine secretion of IL‐1α in amoeboid melanoma cells plays a key role in enhancing the positive feedback crosstalk between rho‐associated protein kinase (ROCK)‐Myosin II and proinflammatory nuclear factor κB (NF‐κB), that supports tumor invasion activity and metastasis.5 The gene discussed is NFKB1; the disease is melanoma.