More specifically, MMP2 exerts an immunosuppressive role both directly (by acting as an autoantigen, thus evading immunosurveillance as well as negatively modulating tumor resident antigen‐presenting cells [APCs] and T cells via deleterious TLR2‐ and TLR4‐signaling) and indirectly (through the immunosuppressive action of CAFs).42, 43. The gene discussed is TLR4; the disease is neoplasm.