Ewing sarcoma are potentially dually vulnerable to transcriptional CDK inhibition: ubiquitous binding of EWSR1::FLI1 at promoter sites results in widespread enhancer re-programming and transcriptional addiction, and the EWSR1::FLI1 transcript itself is relatively long, at more than 4 kb in length [29]. Here, EWSR1 is linked to Ewing sarcoma.