Interestingly, lineage-specific ChRCC signature genes — such as forkhead box I1 (FOXI1), its transcriptional target double-sex and mab-3 related transcription factor 2 (DMRT2), Rh family C glycoprotein (RHCG), and long noncoding RNA LINC01187 (13) — were all downregulated in ChRCCdediff compared with ChRCCclassic (Supplemental Figure 1D). This evidence concerns the gene DMRT2 and chromophobe renal cell carcinoma.