Metaclusters rich in CD44, Ly108, CD101, and GZMB were enriched with CLL coculture and depleted with continuous OPN5 treatment (Supplemental Figure 15B), but this effect was not maintained with CLL cell OPN5 pretreatment (Supplemental Figure 15C). The gene discussed is SLAMF6; the disease is B-cell chronic lymphocytic leukemia.