OPN5 significantly reduced IR expression, induced a shift from TTEX to TPEX (Figure 6, C and D, and Supplemental Figure 16, C and D), and altered the TF profile of T cells from patients with CLL to enrich for more stem-like populations (Figure 6, E and F, and Supplemental Figure 16, E and F). This evidence concerns the gene OPN5 and B-cell chronic lymphocytic leukemia.