MADD and diabetes mellitus: Our PPI studies revealed that 33 of the proteins interacting with MADD have been implicated in diabetes, β cell function, and insulin signaling and that 52% of these interactions were altered by dex30, including with members of the 14-3-3 protein family and STAT1, which are implicated in peripheral insulin signaling and pathogenesis of diabetes in pancreas, muscle, and adipose tissue (72–74).