INS and diabetes mellitus: Furthermore, we performed systematic PubMed searches and found that 35 of the interactors (34.3%) could be linked with diabetes/β cell function/insulin signaling and/or puberty/pituitary function and that 67 (65.7%) have been implicated in cellular functions previously linked with MADD (signaling through ERK1/2 or EGFR; exocytosis, endocytosis, or cell survival) (Figure 6 and Supplemental Table 6).