PTK2 and small cell lung carcinoma: Src inhibition by Saracatinib abrogated ANG-2–dependent SCLC cell migration and intracellular signaling in a similar manner as ITGB1-KO (Figure 7 and Supplemental Figure 8), and Src and Fak showed increased phosphorylation upon ANG-2 stimulation at Tyr-416 and Tyr-397, respectively (Figure 7, A and B).