Similar results were obtained for the Dox-based multiblock copolymer prodrugs as they were the most efficient for tumor growth inhibition, with an optimal molecular weight of about 100 kDa to enhance the antitumor efficacy.218 This versatility of the PHPMA drug delivery platform has also been applied to the co-delivery of Gem and diaminocylohexane platinum (DACH Pt) and of Gem and Ptx by simple copolymerization of the respective monomer prodrugs (or the chelating ligand-bearing monomer in case of DACH Pt).219,220. This evidence concerns the gene GEM and neoplasm.