Immunohistochemistry and western blot showed that T2DM rats presented obviously increased expression of Bax as well as obviously decreased expression Bcl‐2 in aorta, while Pue treatment obviously decreased Bax expression and increased Bcl‐2 expression in the aorta of T2DM rats (Figure 5C,D). Here, BCL2 is linked to type 2 diabetes mellitus.