Researchers have shown that hypoxia induces high expression of KLF4 in different cells, such as human aortic smooth muscle cells (Shan et al., 2020) and pulmonary arteriole smooth muscle cells, in mice with hypoxia‐induced pulmonary hypertension and pulmonary hypertension patients (Sheikh et al., 2015). This evidence concerns the gene KLF4 and pulmonary arterial hypertension.