NFKB1 and familial dilated cardiomyopathy: Inflammation and oxidative stress are implicated in the pathogenesis of DCM, and studies have demonstrated that 6b prevents inflammation, oxidative stress, hypertrophy, fibrosis, and apoptosis in DCM through blocking NF-κB nuclear translocation and activating the Nrf2 pathway both In vitro and in vivo (109).