TNFRSF11B and idiopathic juvenile osteoporosis: Changes in the expression levels of some genes, such as WNT10B, RUNX2, RANKL, Osterix, osteocalcin, osteoprotegerin(OPG), and Sclerosteosis(SOST), have revealed these effects, which sometimes differed in male patients with idiopathic osteoporosis, and their expression levels tended to decrease (135).