In transitional monocytes, MC01, characterized by maximal AAL, Gal-1, Gal-3 and Siglec-1 binding within the group, was significantly underrepresented in SLE (12.2%) in comparison to HC (24.2%), while MC02, demonstrating relatively weaker binding of the aforementioned lectins and low HLA-DR expression, comprised 44.8% of transitional MO cells in HC and 58.7% of the cells in SLE (58.7%) (Figure 8F). The gene discussed is LGALS3; the disease is systemic lupus erythematosus.