LGALS1 and systemic lupus erythematosus: In CD56dim NK-cells, the predominant metacluster MC02 (82.8% in HC) with prominent Gal-1, SNA and Siglec-1 binding was significantly decreased in SLE (75.5%) and second largest metacluster MC01 (9.0% in HC), distinguished by relatively weak lectin binding, was elevated in SLE (12.7%) (Figure 5D).