CD8A and systemic lupus erythematosus: Similarly, in CD8 NKT-cells, MC02 with negligible AAL and Siglec-1 binding, and MC03 with intermediate AAL and low Siglec-1 binding, were enriched in SLE (1.1% and 3.7%, respectively) compared to HC (0.4% and 2.3%, respectively), with the latter difference being statistically significant (Figure 6G).