A total of 798 differential genes were identified based on the IBD dataset (GSE3365), and the heatmap demonstrated the top 20 genes with the most significant up-regulation and down-regulation (Figure 1A), and the volcano plot showed the identified differential genes including 417 up-regulated and 381 down-regulated genes, among which SERPINB2 was the most significant up-regulation gene in the IBD samples. This evidence concerns the gene SERPINB2 and inflammatory bowel disease.