MAPT and Alzheimer disease: Patterns of structural connectivity of the LC to other brain regions—quantified via diffusion MRI (dMRI) (Sun et al., 2020; Levinson et al., 2023)—may further inform us about the pathology distribution in the brain, particularly in the context of Alzheimer’s disease, where some hypothesize that tau protein may transmit neuron to neuron from the LC to other areas (Braak and Del Tredici, 2011).