The CpG sites of CDKN2A (cg18849169, cg26891370, cg04201367, cg11109721, and cg22005145), GPX3 (cg12840719 and cg04026675), and SLC7A11 (cg06623625, cg02734904, cg06206831, cg21877274, cg01309945, cg04474257, and cg24869834) exhibited elevated methylation levels in CRC (Supplementary figure 2A-C). The gene discussed is CDKN2A; the disease is colorectal carcinoma.