Figure 4B displayed that the immune infiltration analysis of STAT4 and its 26 accessory protein molecules (POLDIP3, SEC24A, PWP1, TFAM, LAMTOR5, SMG7, DIS3L, KMT2D, SEC24B, NUP62, NMI, WDCP, PCGF1, ECH1, STAT1, FLOT2, SH2D1B, SEC23B, SEC16A, NUP58, IL12RB2, BCL7A, ALMS1, FLOT1, KLF11, CRK) in homo sapiens, which were contributed to wake up the suppressor T cells and silence antitumor cells in pan cancers, thereby forming an immunosuppressive tumor microenvironment. This evidence concerns the gene SH2D1B and cancer.