IKZF1 alterations will lead to acquisition of stem cell‐like features, metabolic reprogramming, and resistance to drugs and immunotherapies,7, 9, 10, 16, 17, 28, 29, 30 underscoring the importance of targeting IKZF1 deletions in Ph‐like ALL. Here, IKZF1 is linked to acute lymphoblastic leukemia.