Sun and collaborators demonstrated that the mechanism by which the photosensitizer B5-aminolevulinic acid (5-ALA) exerts antitumoral effects in mouse models of colorectal cancer, is achieved by ICD induction, depending on protein kinase B (AKT) inhibition and effective activation of bone-marrow derived dendritic cells (Sun et al., 2023). This evidence concerns the gene AKT1 and colorectal cancer.