They utilized two murine models very similar to human MASH-induced HCC: a) the HFD MUP-uPA mice, in which overexpression of urokinase plasminogen activator induces ER stress in hepatocytes (Nakagawa et al., 2014) and b) the STAM mice, in which a streptozotocin injection combined with HFD is applied (Fujii et al., 2013). Here, PLAU is linked to hepatocellular carcinoma.