KLK3 and pachyonychia congenita: Patients with metastatic disease (mCRPC or mCSPC) at study entry were mainly at TNM stage IVb, and compared to patients with localised/locally advanced PC, were more likely to have a histological PC type of ductal adenocarcinoma, higher Gleason scores, and higher mean PSA values, which are factors associated with poorer PC outcomes [27–30].