In summary, the findings observed in response to TAZ knockdown demonstrated that a decrease in LIMK1 and phosphorylated cofilin caused actin depolymerization, while a reduction in MLCK and phosphorylated MLC2 led to the disassembly of stress fibers and focal adhesions, ultimately resulting in a decrease in breast cancer cell migration. The gene discussed is CFL1; the disease is breast carcinoma.