For instance, interventions with vascular endothelial growth factor receptor 2 (VEGFR2) blockade or the AMPK signaling activator, 5-aminoimidazole-4-carboxamide riboside (AICAR), have shown promising shifts in mitochondrial biogenesis and cancer cell behaviors by modulating PGC1α. The gene discussed is PRKAA1; the disease is cancer.