In addition, the phosphoserine aminotransferase 1 (PSAT1)’s interaction with p5372P variant in HCC cells dissociates PGC1α binding, promotes PGC1α’s nuclear translocation (84), mitochondrial transcription factor A (TFAM)-mediated OXPHOS and TCA cycle activation (15). Here, PPARGC1A is linked to hepatocellular carcinoma.