For example, from the latest studies, PGC1α expression is upregulated in ovarian cancer (OC), colorectal cancer (CRC), gastric cancer (GC), nasopharyngeal (NPC) and cholangiocarcinoma (CCA), while downregulated in thyroid cancer (TC), liver cancer and renal cancer. The gene discussed is PPARGC1A; the disease is thyroid gland carcinoma.