Additionally, PGC1α boosts leucyl-tRNA synthetase 1 (LARS1) expression, further stimulating AKT/GSK-3β signaling (37).WNT/β-catenin pathway can also be activated by PGC1α, which promotes CRC cell proliferation and inhibits apoptosis (37, 39). This evidence concerns the gene PPARGC1A and colorectal carcinoma.