In 2020, Prasad et al. expanded the 2-marker panel to a 5-marker panel (VAV3, ZNF682, NDRG4, FER1L4, ZNF568) for the detection of BE and EAC, achieving sensitivities of 92.0% for BE and 100.0% for EAC (Iyer et al., 2020). This evidence concerns the gene ZNF682 and Barrett esophagus.