The cGAS-STING-IFN-I axis in the brain has emerged as a significant contributor to the pathogenesis of various neurodegenerative diseases, including AD, Parkinson’s disease, frontotemporal dementia, amyotrophic lateral sclerosis, and Down syndrome (Sliter et al., 2018; McCauley et al., 2020; Yu et al., 2020; Roy and Cao, 2022). The gene discussed is STING1; the disease is Down syndrome.