MEF2C and tauopathy: Loss of MEF2C is associated with heightened IFN-I signature in microglia during aging and β-amyloidosis, while IFN-I signaling in neurons diminishes MEF2C-associated cognitive resilience in tauopathy (Deczkowska et al., 2017; Barker et al., 2021; Xue et al., 2021; Udeochu et al., 2023).