SREBF1 and liver dysplastic nodule: Overexpression of sterol regulatory element-binding protein-1 (SREBP-1) mediates abnormal lipid accumulation in DN renal tubular epithelial cells, and inhibiting the PI3K/Akt pathway can reduce SREBP-1 expression and lipid accumulation, indicating that the PI3K/Akt signaling pathway plays an important role in mediating high glucose-induced SREBP-1 expression in DN renal tubular cells [37].