Nonetheless, another study showed that FXR antagonists inhibit hepatic gluconeogenesis through the FXR/miR-22-3p/PI3K/AKT/FoxO1 pathway and promote glycogen synthesis via the FXR/miR-22-3p/PI3K/AKT/GSK3β pathway, thereby improving glucose homeostasis in T2DM mice (44).In addition, it is currently believed that defects in Anion exchanger-2 (AE2), a Cl-/HCO3- exchanger located in the apical membrane of the BEC that pumps HCO3- out of the cell, is one of the main contributors to changes in bile acid metabolism. Here, NR1H4 is linked to type 2 diabetes mellitus.