In a retrospective cohort study in China, T2DM was found to be one of the major metabolic risk factors for PBC, with 11.9% of patients with T2DM having lower albumin, platelet counts and a higher rate of cirrhosis than non-T2DM patients; however, 54.3% of these patients also had hyperlipidemia, hypertension and NAFLD (9), which caused some interference in the study. This evidence concerns the gene ALB and type 2 diabetes mellitus.