Jiang et al. found that curcuminoid VI improves depression-like behavior in CMS mice based on the SPT, TST, and FST, which is associated with the transition of glial cells in the hippocampus from a proinflammatory phenotype (iNOS-Iba1) to a neuroprotective phenotype (Arg-1-Iba1). The gene discussed is AIF1; the disease is major depressive disorder.