As shown in Figure 7, the combination of bsPD-L1 and MMP status had higher predictive accuracy to identify NSCLC patients without benefit from ICI treatment than tumor PD-L1 expression, which is used in routine diagnostics for patient selection (Hino et al., 2010; Taube et al., 2014; Garon et al., 2015). This evidence concerns the gene CD274 and non-small cell lung carcinoma.