The main active substances of the volatile metabolites of agarwood regarding sleep-promoting, anti-anxiety and anti-depression effects are mainly 4 2-(2-phenylethyl) chromones, and the main targets are AKT1, ALB, IL6, GAPDH and TNF target proteins, of which ALB and TNF have the best activity, and the content of 4 different chromones in four forms of agarwood is TT > HL > CL > BT. This evidence concerns the gene ALB and major depressive disorder.