KLK3 and Familial prostate cancer: An article on “Prostate Cancer Screening” recommended that annual PSA screenings for prostate cancer must be started at the age of 45 years in high-risk individuals (a family history of either prostate cancer or multiple cancers, known high-risk germline mutations such as BRCA 2 or African ethnicity) and at 50 years of age for men at average risk, after informing them about the pros and cons of the screening test.