To delineate the transcriptome profile of tumor cells, we performed an unsupervised cell clustering analysis, which revealed 14 unique cell clusters (endothelials, epithelials, effector T cells, CD4+ T cells, plasmacytes, endocrine cells, proliferative cells, fibroblasts, mast cells, B cells, DCs, pericytes, monocytes, and macrophages; Figure 4C), each defined by marker genes (Figure S23A; see Supplementary File 3). The gene discussed is CD4; the disease is neoplasm.