VCAN and gastric cancer: Figure S15D elucidated the reliable predictive capability of the PRS for the prognosis of patients with GC in TCGA cohort. The PRS had a positive effect on the prognosis of patients with GC (Figure S15E-F). PCA showed that the PRS could distinguish the entire GC patient population (Figure S15G). The correlation plots demonstrated the associations among PTPRJ, BATF2, RGS1, and VCAN expression levels and the PRS (Figure S15H). We further developed a nomogram of six readily available clinical features to guide the individualized management of patients with GC (Figure S15I).