Prostate-specific membrane antigen (PSMA), also known as FOLH1 or GCP II, is a folate gamma glutamyl carboxypeptidase that is highly expressed in more than 90% of PCa lesions—including primary lesions, LNMs, and bone metastases—with 100-1000-fold higher expression level than that in normal prostate (NP) tissues 4, 5. The gene discussed is FOLH1; the disease is posterior cortical atrophy.