EPAS1 and ischemic stroke: In the acute stage upon focal ischemic stroke neuroprotection as seen in nPhd2 Δ/Δ mice was absent, as infarct lesion size (♀: 88 ± 25 vs 71 ± 5 mm3, p = 0.122, n = 10-12; ♂: 75 ± 30 vs 69 ± 26 mm3, p = 0.680, n = 9-10), cerebral edema and neurological impairment were comparable in nPhd2/Hif1a/Hif2a ΔΔΔ/ΔΔΔ and Phd2/Hif1a/Hif2a fff/fff mice (Figure 1C).