In order to elucidate whether potential HIF-dependent reprogramming of the neuronal metabolism contributes to the improved outcome after ischemic stroke, we first analyzed the expression of HIF target genes, whose function is related to glucose metabolism, in neuronal cultures derived from newborn nPhd2 Δ/Δ and nPhd2/Hif1a/Hif2a ΔΔΔ/ΔΔΔ mice. Here, EPAS1 is linked to ischemic stroke.