Building upon our prior investigations that delineated unique neuropathological attributes of EV71 infection in brainstem encephalitis within hSCARB2-Tg mice, encompassing gliosis, escalated proinflammatory cytokine levels, and polio-like paralysis-like symptoms 4, we also evaluated the potential mitigation of these characteristics via insulin treatment. The gene discussed is INS; the disease is poliomyelitis.