Here, we reported two patients harboring biallelic variants in the GEMIN5 gene and suffering from early‐infantile developmental and epileptic encephalopathies (EIDEE) (Zuberi et al., 2022), but otherwise presenting with clinical features distinct from NEDCAM syndrome, broadening the phenotypic spectrum of GEMIN5. The gene discussed is GEMIN5; the disease is early-infantile DEE.