HDGF and Alzheimer disease: It is known to signal via stimulating multiple pathways, such as MAPK and/or PI3K, and increasing the production of growth factors, including vascular endothelial growth factor (VEGF) that may possess anti‐apoptotic properties.[42] Intriguingly, it has been reported to be increased in synaptic fraction of human brains from frail patients as they became cognitively impaired but not in patients with the diagnosis of AD.[43] Thus, the increase in HDGF in our hiPSC‐neurons early in development of AD may represent a counterresponse, which if enhanced could be beneficial.