Also downregulated is BCLF1 (or BCLAF1 protein, Bcl‐2‐associated transcription factor 1), which is involved in apoptosis, autophagy, and transcriptional control, as previously identified in tumorigenesis models.[45] However, enhancement of its activity has been suggested to improve neurological dysfunction in the context of AD model systems.[46] Thus, BCLF1 may also represent a novel therapeutic target in AD excitatory neurons. Here, TSN is linked to Alzheimer disease.