FBN1 and Rare disease with thoracic aortic aneurysm and aortic dissection: An estimated rate of 3.75% in parental mosaicism and 0.3% rate in affected patients were estimated in 1085 patients with thoracic aortic aneurysm and dissection (TAAD) by Yang et al. [38], and 4.8% parental mosaicism rate in 333 patients with FBN1 pathogenic variants by Chesneau et al. [39].