FBN1 and Marfan syndrome: Variants in FBN1 have been reported in a wide range of autosomal dominant heritable connective tissue disorders, including MFS [4], acromicric dysplasia (OMIM 102,370) [5], isolated ectopia lentis (OMIM 129,600) [6], geleophysic dysplasia type 2 (OMIM 614,185) [5], Marfan lipodystrophy syndrome (OMIM 616,914) [7], MASS syndrome (OMIM 604,308) [8], stiff skin syndrome (OMIM 184,900) [9], Weill–Marchesani syndrome type 2 (OMIM 608,328) [10], and familial ascending aortic aneurysm and aortic dissection [11].