Despite the higher number of CD11b-positive cells in Tg2576 compared to WT mice, none of the inflammation-related genes modified by aging in control Tg2576 mice, such as P2ry12, Csf3, Cxcr1, ApoE, Trem2, are included in microglia-associated molecular phenotypes in AD mouse models [32, 59]. This evidence concerns the gene P2RY12 and Alzheimer disease.