CCL4 and Cognitive impairment: Instead, most of the genes differentially expressed between 3.5 and 5 months in Tg2576 mice are preferentially associated with astrocytes, such as Ccl4 [60] and Ccr2 [61], a deficiency of which impairs astroglial signaling for microglial accumulation and accelerates the progression of AD-like disease [62], and Cxcl10 [63], the dysregulation of which has been associated with cognitive defects in aging [64].