In fact, all of them have been identified as upregulated in AD patients and/or AD animal models (CCL2 [33], CCR5 [34], CD61 [35], CC88 [36], P2 × 7R [37], CD253 [38]) However, in line with the subpopulation-specific gene expression, none of the analyzed double positive cells ratio resulted modified within experimental groups, due to the expression of hAPP mutated gene and/or DSS induction (Supplementary Fig. 3). Here, CCL2 is linked to Alzheimer disease.