Sohrabi et al. [42] induced DSS colitis in AppNL−G−F mice, a strain which develops early cortical amyloidosis and cognitive impairment at 2 and 6 months respectively, and which showed an increased insoluble Aβ–40/42 levels and decreased microglial CD68 immunoreactivity compared to vehicle-treated mice. The gene discussed is CD68; the disease is colitis.